Bristol-Myers Squibb pursues cancer biomarker development deal
Bristol-Myers Squibb will collaborate with Adaptive Biotechnologies to develop immunological biomarkers for cancer, representing another step forward in the development of personalized medicine.
9 blood-based biomarkers correspond to amyloid plaque in the brain
Researchers in Australia have identified 9 blood-based biomarkers that correspond with PET imaging measurements of amyloid beta protein, a brain plaque that can signify the advance of Alzheimer's disease.
CV biomarker study finds evidence of bias, exaggeration in the field
Scanning the field of biomarker research for cardiovascular disease, a group of investigators has found some compelling data that suggest the effect of thebiomarkers is regularly exaggerated, with signs of bias in the reports. And that clearly could be hurting the medical field's understanding of the biomarkers' significance.The investigators identified 59 available meta-analyses for review with 49 claiming statistically significant results, according to a report in Cardiology Today. But the largest studies with the most subjects had the smallest effects, with a host of smaller studies claiming the most dramatic results. And that indicates bias in the selection of which reports were published, tilting the field toward the positive and away from the negative. Read the full story >>
Work advances on early-detection ovarian cancer blood Dx
A blood test to determine a patient's suicide risk may be within reach. Scientists at the University of New South Wales in Australia and colleagues in Sweden believe they've come up with a viable diagnostic biomarker: higher-than-normal levels of the neurotransmitter quinolinic acid. Through their work with an unnamed biotech, they expect to debut a working blood test for human clinical trials within the next year, the Australian Times reports. Ideally, such a test would process results with a day or two, enabling targeted personalized medicine-style treatments specific to reducing levels of quinolinic acid. Read more >>
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Fetus secretes hormone that could flag preeclampsia risk
The hormone adrenomedullin is secreted by the fetus during pregnancy and appears to keep pregnant women from developing preeclampsia. And they believe it could become an effective biomarker to help pinpoint patients more likely to develop the dangerous condition.
Blood protein could mark atherosclerosis
Researchers at the Montreal Heart Institute have ferreted out a blood protein that could help diagnose atherosclerosis, a thickening of the arterial wall that can lead to heart attack.
Biomarker trio enables blood Dx to map heart attack risk
Another team of researchers is tackling the task of developing a blood test designed to predict a patient's likelihood of suffering a heart attack. And they've zeroed on three promising biomarkers to help get the job done.
Genome mutations reveal acute myeloid leukemia risk, potential drug targets
New genetic and epigenetic alterations in the genome discovered by scientists at The Cancer Genome Atlas Research Network offer promising disease markers for acute myeloid leukemia--a finding that may have narrowed the search for drug targets.
Investigators raise doubts about VEGF as a driver behind prostate cancer
A group of investigators say they put one theory related to prostate cancer to the test, and came up with some data indicating it's a dead end for developers as well as doctors looking for the right therapeutic strategy for patients.
International Parkinson's biomarkers trial begins
A massive, international study to find and evaluate potential Parkinson's disease biomarkers has finished enrolling a first group of 600 Parkinson's patients and controls.
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Natick, MA-based Karyopharm Therapeutics has banked $48.2 million in Series B cash. The funds will be used to advance its pipeline of selective inhibitors of nuclear export (SINE) drug candidates for hematologic and solid tumors.
The agency has given the coveted status to the Lexington, MA-based biotech company's experimental treatment for use against early onset lysosomal acid lipase deficiency, an inherited disorder that typically kills infants within the first 6 month of life, according to the company.





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